Endocrine Abstracts

Introduction: Atypical parathyroid adenoma (APA) is rarely encountered cause of primary hyperparathyroidism (PHPT). No definite criteria are considered to distinguish preoperatively APA from parathyroid typical adenoma or carcinoma.The aimTo describe the clinical course of a patient with an atypical parathyroid adenoma with severe hypercalcemia and multiple fragility fractures.Case presentation: A 61-year-old...

Background: In most cases of parathyroid carcinoma (PC) only recurrence could be a credible feature of malignancy.Clinical case: At the age of 19 years a woman was diagnosed with urolithiasis. At the age of 22 years she had a surgical resection of the neck nodule at the right site in the projection of carotid triangle. After the histological study, ectopic parathyroid tumor was misdiagnosis with paraganglioma (material is available for review). At the ag...

An 86-year old man was admitted to hospital with gradual decline in mobility and leg weakness. Co-morbidities included atrial fibrillation, hypertension and osteoarthritis. The adjusted serum calcium on admission was 3.42 mmol/l; bone profile showed phosphate 0.56 mmol/l, alkaline phosphatase 140 U/l, albumin 34 g/l, parathyroid hormone 21.4 pmol/l. He was vitamin-D replete (68 nmol/l) with normal renal function. The hypercalcaemia was not thought to be due to any medications....

Background: Obese children are at greater risk of fracture. However, previous evidence suggests that obese children with a mutation in the melanocortin-4 receptor (MC4R) have a high age-adjusted bone mass. MC4R deficiency is associated with increased linear growth, so bone mass may be over-estimated due to patients being taller. We therefore aimed to compare body size-adjusted bone mass of lean and obese pre-pubertal children with those who have a mutation in MC4R.<p class...

Introduction: Co-production refers to working in partnership with service-users to improve provision of services. Increasing evidence highlights that co-production can improve health care and result in financial savings. Service-users are involved in defining the problem or need, creating the solution, delivering it, and evaluating it. This approach demands longer-term engagement by service-providers but leads to sustainable change. Graphic facilitation is the use of large-sca...

Introduction: Patients with primary adrenal insufficiency (PAI) and patients with congenital adrenal hyperplasia (CAH) receive life-long glucocorticoid (GC) replacement therapy. Today daily GC doses are still higher than the reported adrenal cortisol production rate, and are not able to reproduce the physiological secretion pattern. This might result in long-term morbidities such as osteoporosis. Until now no prospective trial was performed investigating the long-term effect o...

Ipilimumab, pembrolizumab, and nivolumab – novel immune checkpoint blockade drugs – are increasingly used in the treatment of metastatic melanoma and other cancers. Ipilimumab is an anti-cytotoxic T-lymphocyte antigen 4 (CTLA4) MAB and the first drug shown to improve overall survival in metastatic melanoma. Hypophysitis is a widely described side-effect linked with both lymphocytic inflammation and a direct toxic effect on the pituitary in mouse studies, but has been...

Background: In diabetes, exposure to frequent episodes of hypoglycaemia diminishes a persons awareness of hypoglycaemia, by poorly defined mechanisms. Evidence suggests that, at least in part, changes in cell behaviour within the ventromedial hypothalamus may contribute to this defect and that changes in AMP-activated protein kinase (AMPK), a key glucose-sensing enzyme are involved. Evidence suggests there are (mal)adaptations within neurons, however, little is known about cha...

The aim of the research was to reveal and assess the interaction between environmental and hereditary factors in obese patients seeking for weight loss.Materials and methods: We analysed the anamnesis of 134 overweight and obese patients, having asked to endocrinologist for losing weight (20 men and 112 women). The mean age of the respondents was 45.78+8, 76 years. 15.7% of patients were overweight, and 84.3% were obese. Heritability of obesity was deter...

Backgrounds and aim: Millions of people all over the world are in a search for the perfect weight loss plan. The aim of our research was to make a typical portrait of a Belarusian citizen who is trying to lose weight.Methods: Participants were individuals (n=70) who were screened for a behavioral weight-loss treatment program. The majority of patients were women (88.4%). The mean age was 46.56+9.43 years. Among the participants three of 70 perso...